Background/Objectives: Polycystic ovary syndrome (PCOS) is a prevalent endocrine condition in women. The impacts on oral and dental health have not been explicitly articulated. This study aimed to ascertain the association between serum asprosin levels, DMFT, and periodontitis in women with polycystic ovary syndrome (PCOS). Methods: The study included 100 participants: 60 women with PCOS and 40 healthy individuals. Clinical attachment loss (CAL), probing pocket depth (PPD), plaque index (PI), and gingival bleeding index (GBI) were documented. An enzyme-linked immunosorbent assay (ELISA) was used to measure serum asprosin and HOMA-IR concentrations. Results: An individual diagnosed with DMFT and periodontitis in women with PCOS had a markedly elevated concentration of asprosin (5.67 ± 3.55 ng/mL) compared to the control group (3.23 ± 2.25 ng/mL; p < 0.0001). The correlation between serum asprosin levels and clinical periodontal markers was found to be significantly positive. Conclusions: This case-control study suggests that elevated serum asprosin levels in women with polycystic ovary syndrome (PCOS) may be associated with poor periodontal sensitivity to proinflammatory stimuli.
Jumaah et al. (Wed,) studied this question.