Coumarin-Mediated Inhibition of Diadenylate Cyclase Correlates with Impaired Biofilm Formation in Streptococcus mutans

Key Points

• The aim is to evaluate how coumarin affects diadenylate cyclase activity and biofilm formation in Streptococcus mutans.
• In vitro analysis of coumarin's effects on diadenylate cyclase activity.
• Assessment of biofilm formation in Streptococcus mutans after coumarin treatment.
• Coumarin significantly inhibits diadenylate cyclase activity (p<0.01).
• Impaired biofilm formation observed with coumarin treatment compared to control.