Multimorbidity and cardiometabolic multimorbidity were significantly associated with a larger brain-age gap in dementia-free older adults (p<0.05).
Observational (n=1,151)
Is multimorbidity burden and cardiometabolic multimorbidity associated with a larger brain-age gap in dementia-free older adults?
Cardiometabolic multimorbidity and overall chronic disease burden are associated with advanced structural brain aging in dementia-free older adults.
p-value: p=<0.05
Abstract INTRODUCTION Emerging evidence has linked chronic diseases with structural brain measures; however, the relationship between multimorbidity patterns and brain–age gap is unclear. METHODS This community‐based study involved 1151 dementia‐free older adults in Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND‐China). Multimorbidity was defined as coexistence of two or more chronic diseases. Hierarchical cluster analysis was used to identify five patterns of multimorbidity. We additionally defined cardiometabolic multimorbidity as coexistence of two or more cardiometabolic diseases. The predicted brain age was estimated using DeepBrainNet. Data were analyzed using linear regression models. RESULTS The number of chronic diseases, multimorbidity, and cardiometabolic multimorbidity were significantly associated with larger brain–age gap ( p < 0.05). The multimorbidity clusters comprising cerebrovascular disease and metabolic disorders or biliary tract diseases, dorsopathies, anemia, and hearing problems were significantly correlated with larger brain–age gap ( p < 0.05). DISCUSSION The overall burden and cardiometabolic pattern of multimorbidity are associated with advanced brain aging in dementia‐free older adults.
Liu et al. (Wed,) conducted a observational in Dementia-free older adults (n=1,151). Multimorbidity and cardiometabolic multimorbidity vs. Lower burden of chronic diseases was evaluated on Brain-age gap estimated using DeepBrainNet (p=<0.05). Multimorbidity and cardiometabolic multimorbidity were significantly associated with a larger brain-age gap in dementia-free older adults (p<0.05).