Copper-catalyzed synthesis of benzofuro3,2-cpyridine derivatives

Key Points

• This research aims to develop a method for synthesizing benzofuro[3,2-c]pyridine derivatives using copper catalysis.
• The synthesis utilizes copper sulfate and DTBP in a nitrogen atmosphere.
• 2-methylpiperidine is oxidized to an imine, then coupled with phenolic compounds.
• Further oxidation yields the final product with high efficiency.
• The method achieved high efficiency in synthesizing benzofuro[3,2-c]pyridine derivatives.