Clinical Validation of Unani Pharmacopoeial Formulation “Iṭrīfal Shahtara and Sharbat Unnab” in Cases of Buthūr (Macules/Pustules)

Background: Buthūr (macules/pustules) are a common symptom of many skin diseases, often causing social distress. These skin alterations require effective treatment, but a safe and proven cure has not yet been found. Ongoing research aims to develop natural, low-side-effect, cost-effective, and widely accepted treatments. The Unani System of Medicine, with its centuries-old therapeutic remedies, offers potential solutions. This study aimed to validate two Unani formulations – Iṭrīfal Shāhtara and Sharbat ‘Unnāb – which are commonly used for treating Buthūr but lack scientific validation. Materials and Methods: The study was conducted at the Regional Research Institute of Unani Medicine, Bhadrak, Odisha, involving 103 patients. Iṭrīfal Shāhtara (5 g) was administered orally with water twice a day, while Sharbat ‘Unnāb (20 ml) was given similarly for 21 days. Clinical assessments were made at baseline and on days 7, 14, and 21 using a Visual Analog Scale (VAS). Results: Both formulations provided relief in 91.26% of cases, with significant clinical improvement and changes in VAS score. Statistical analysis showed a significant difference at the 5% level using one-way analysis of variance. Conclusion: The study concludes that the drugs Iṭrīfal Shāhtara and Sharbat ‘Unnāb are effective in treating Buthūr , improving symptoms without side effects. The treatments were well tolerated, and no adverse effects were observed during the study.