Why the study?
Takotsubo syndrome pathogenesis is poorly understood, but outcome differences across triggering factors suggest distinct pathophysiological mechanisms across InterTAK classifications and between primary and secondary Takotsubo syndrome.
Does the triggering factor and classification of Takotsubo syndrome influence the myocardial tissue response as assessed by cardiovascular magnetic resonance imaging?
Population
110 Takotsubo syndrome patients from the InterTAK registry
Comparison
InterTAK classification groups and primary vs secondary Takotsubo syndrome
Design
Multicenter cohort study
Key result
Emotional triggers in Takotsubo syndrome were associated with larger myocardial edema (72% vs 60%; P<0.01), whereas secondary TTS had more frequent late gadolinium enhancement (54% vs 19%; P<0.01).
Authors
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Emotional triggers linked to greater edema and secondary TTS to more LGE on CMR; extends pathophysiologic insights but leaves open management implications.
Cohort (n=110)
Yes
Does the triggering factor and classification of Takotsubo syndrome influence the myocardial tissue response as assessed by cardiovascular magnetic resonance imaging?
Absolute Event Rate: 72% vs 60%
p-value: p=<0.01
Cardiovascular magnetic resonance imaging reveals that emotionally triggered Takotsubo syndrome is associated with greater myocardial edema, whereas secondary Takotsubo syndrome is more frequently associated with direct myocardial damage evidenced by late gadolinium enhancement.
Gotschy et al. (2026) conducted a cohort in Takotsubo syndrome (n=110). Emotional triggers vs. Physical triggers was evaluated on Extent of myocardial edema (p=<0.01). Emotional triggers in Takotsubo syndrome were associated with larger myocardial edema (72% vs 60%; P<0.01), whereas secondary TTS had more frequent late gadolinium enhancement (54% vs 19%; P<0.01).