Key result
Cardiac CT yields 94% NPV for 1-year adverse events in suspected prosthetic valve dysfunction.
Why the study?
Prosthetic valve dysfunction is potentially life-threatening yet often challenging to diagnose, prompting evaluation of the negative and positive predictive value of cardiac CT.
Does cardiac computed tomography accurately diagnose prosthetic valve dysfunction in patients with suspected PVD?
Cohort (n=64)
Does cardiac computed tomography accurately diagnose prosthetic valve dysfunction in patients with suspected PVD?
Cardiac CT has a high negative predictive value for ruling out major adverse events in suspected prosthetic valve dysfunction, supporting its use as a reliable diagnostic modality.
May aid suspected PVD diagnosis; hypothesis-generating and requires prospective validation before clinical use.
Background Prosthetic valve dysfunction (PVD) is potentially life-threatening, yet often challenging to diagnose. We aimed to determine the negative and positive predictive value (NPV, PPV) of cardiac computed tomography (CT) in clinically suspected PVD. Methods Consecutive patients with prosthetic heart valves (PHVs), who underwent clinically indicated CT for suspected PVD between January 2017 and June 2024, were retrospectively assessed. CT scans with adequate image quality were evaluated and classified (abnormal: periprosthetic masses; structural valve deterioration (SVD); restricted leaflet motion). Valve-related adverse events and follow-up imaging were assessed to evaluate the diagnostic performance. Results Of all 64 patients (58.6 ± 16.9 years, 42.2% female), 68.8% had mechanical, 18.8% bioprosthetic, and 12.5% transcatheter PHV. CT findings were normal in 34 (53.1%) patients, with an NPV of 94% for ruling out device-related adverse events within a follow-up of 1 year. Among 30 (46.9%) patients with abnormal CT findings, a periprosthetic mass was identified in 21 (70%), including pannus ( n = 10), thrombus ( n = 6), vegetations ( n = 3). SVD was observed in 2 patients (6.7%). Among 23 patients with mechanical PHVs, 18 (78.3%) exhibited restricted leaflet motion. Surgical interventions confirmed CT abnormalities in 7/10 patients, yielding a 70% PPV. Conclusion This study is the first to demonstrate the high negative predictive value of CT for ruling out significant PVD-related complications, reinforcing its role as a reliable modality for ruling out major adverse events. While the PPV for identifying underlying PVD pathologies was moderate, CT effectively identified structural abnormalities that required intervention, supporting its clinical usefulness for comprehensive assessment of suspected PVD.
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Voortman et al. (2026) conducted a cohort in Suspected prosthetic valve dysfunction (n=64). Cardiac computed tomography (CT) was evaluated on Negative and positive predictive value (NPV, PPV) of cardiac CT (NPV 94%, PPV 70%). Cardiac computed tomography in suspected prosthetic valve dysfunction demonstrated a 94% negative predictive value for ruling out adverse events at 1 year and a 70% positive predictive value.
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