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Comparative investigation of sodium citrate buffers on lipid nanoparticles, indicating tailored optimization for mRNA and circRNA delivery.
expression of circRNA LNPs but not mRNA LNPs. Second, relative to SM-102 LNPs, MC3-LNPs showed a lower RNA expression efficiency in mice, especially for circRNA. Third, LNPs formulated using high-concentration sodium citrate buffer showed comparable integrity of mRNA and circRNA after multiday storage at room temperature. Overall, our findings underscore the differential impact of citrate buffer concentrations on different LNPs loaded with circRNA and mRNA, calling for the customized optimization of different LNPs for the delivery of mRNA and circRNA.
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Zhou et al. (2026) studied this question.
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