What does this research mean for the field?

Angiostrongylus cantonensis infection causes profound, host-specific dysregulation of the gut microbiome and metabolome, specifically disrupting lipid and bile acid metabolism and yielding potential metabolic biomarkers for early diagnosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize changes in gut microbiota and host metabolism following Angiostrongylus cantonensis infection in rats and mice.

July 3, 2026Infectious Diseases of PovertyOpen Access

Dynamic alterations and potential roles of gut microbiota and metabolites in Angiostrongylus cantonensis-infected mice and rats

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Authors

YHYue HuSun Yat-sen University JCJian-Song Chen MZMinyu ZhouMinistry of Education of the People's Republic of China

Discussion

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Implication

Randomized trial investigates gut microbiota changes and metabolic biomarkers in Angiostrongylus cantonensis-infected hosts, suggesting diagnostic implications.

Key Points

To characterize changes in gut microbiota and host metabolism following Angiostrongylus cantonensis infection in rats and mice.
Infection of BALB/c mice and Sprague Dawley rats with 30 or 100 third-stage larvae (n=10/group)
Analysis of gut microbiota using 16S rRNA gene sequencing and metagenomics
Profiling of host metabolism via untargeted and targeted metabolomics using ultraperformance liquid chromatography-mass spectrometry.
Significant gut microbiota dysbiosis observed, with Firmicutes decreasing and Bacteroidetes increasing in infected hosts (P<0.05).
Prevotellaceae increased in infected mice but decreased in rats (P<0.05).
Identified metabolites such as phosphatidylcholine and 2-carboxylic acid as potential early diagnostic biomarkers.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a4753c55c29257aa2579bc3 https://doi.org/10.1186/s40249-026-01436-7

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July 3, 2026Infectious Diseases of PovertyOpen Access

Dynamic alterations and potential roles of gut microbiota and metabolites in Angiostrongylus cantonensis-infected mice and rats

View Full Paper

Ask AI

Bookmark

Authors

YHYue HuSun Yat-sen University JCJian-Song Chen MZMinyu ZhouMinistry of Education of the People's Republic of China

Discussion

Member takes

Implication

Randomized trial investigates gut microbiota changes and metabolic biomarkers in Angiostrongylus cantonensis-infected hosts, suggesting diagnostic implications.

Key Points

To characterize changes in gut microbiota and host metabolism following Angiostrongylus cantonensis infection in rats and mice.
Infection of BALB/c mice and Sprague Dawley rats with 30 or 100 third-stage larvae (n=10/group)
Analysis of gut microbiota using 16S rRNA gene sequencing and metagenomics
Profiling of host metabolism via untargeted and targeted metabolomics using ultraperformance liquid chromatography-mass spectrometry.
Significant gut microbiota dysbiosis observed, with Firmicutes decreasing and Bacteroidetes increasing in infected hosts (P<0.05).
Prevotellaceae increased in infected mice but decreased in rats (P<0.05).
Identified metabolites such as phosphatidylcholine and 2-carboxylic acid as potential early diagnostic biomarkers.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a4753c55c29257aa2579bc3 https://doi.org/10.1186/s40249-026-01436-7

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