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Demonstrates enhanced glioma therapy through dual-targeting, suggesting new treatment strategies.
, the nanoparticles showed enhanced uptake and cytotoxicity in TfR1/EGFR double-positive U87 glioma cells. In an orthotopic U87 glioma mouse model, DOX@FTn-EGFRAfb significantly inhibited tumor growth and prolonged survival without obvious systemic toxicity. This work presents a versatile protein-engineering strategy for dual-targeted glioblastoma drug delivery.
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Chen et al. (2026) studied this question.
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