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This research investigates how TRPC5 interacts with TRPV1 in the context of neuropathic pain.

July 3, 2026NeuropharmacologyOpen Access

TRPC5 as a Modulator of TRPV1 Signalling in Pathological Pain States

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Randomized trial exploring TRPC5 modulation of TRPV1 signalling in pathological pain, suggesting therapeutic potential.

This research investigates how TRPC5 interacts with TRPV1 in the context of neuropathic pain.
Analyzed TRPC5 mRNA levels in dorsal root ganglia of mice with oxaliplatin-induced pain.
Conducted calcium imaging to assess TRPC5 modulation by LPCs and HETEs.
Used pharmacological agents to inhibit TRPC5 and observed effects on TRPV1 responses.
TRPC5 mRNA is significantly upregulated in models of oxaliplatin-induced pain (p<0.01).
Pharmacological inhibition of TRPC5 reduced TRPV1-induced calcium responses in specific cells (p<0.05).
Identify a physical interaction between TRPC5 and TRPV1 using FLIM-FRET, indicating a direct modulatory relationship.

Müller et al. (2026) studied this question.

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