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July 3, 2026Journal of Child and Adolescent Psychopharmacology

Beyond the Wait-and-See: Data-Driven Decision Points for Guiding Selective Serotonin Reuptake Inhibitor Treatment and Cognitive Behavioral Therapy in Pediatric Anxiety Disorders

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Authors

JSJulia N. StimpflJMJeffrey A. MillsKDKatherine K. Dahlsgaard

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Overview

Randomized trial identifies early predictors of treatment response in youth with anxiety disorders, suggesting better care strategies.

Key Points

  • The aim is to find early markers that can predict treatment response in youth with anxiety disorders undergoing either CBT, SSRIs, or both.
  • Analyzed data from the Child/Adolescent Anxiety Multimodal Study with youth aged 7-17
  • Randomized participants to sertraline, CBT, combined treatment, or placebo
  • Used regression models and ROC analyses to assess improvement trajectories and predict responses.
  • Sertraline group showed 60.8% response probability with ≥25% PARS improvement at week 4 (p=0.001)
  • In CBT group, ≥25% improvement predicted a 47.9% response chance at week 4 (p=0.025)
  • Combined treatment showed a 73.3% response probability with ≥25% improvement at week 4 (p<0.001).

Cite This Study

Stimpfl et al. (2026) studied this question.

synapsesocial.com/papers/6a47540e5c29257aa2579efbhttps://doi.org/10.1177/10445463261462882
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RCT shows ways to predict if SSRIs, CBT, or both are best for anxiety2026
  2. 2A Pragmatic SMART Study of Medication and CBT Sequencing in Pediatric Anxiety Disorders: A Randomized Clinical Trial2026 · 3 citations
  3. 3Patterns of sub‐optimal change following <scp>CBT</scp> for childhood anxiety2024 · 4 citations
  4. 4Trajectory and Magnitude of Response in Adults with Anxiety Disorders: A Bayesian Hierarchical Modeling Meta-Analysis of Selective Serotonin Reuptake Inhibitors, Serotonin Norepinephrine Reuptake Inhibitors and Benzodiazepines2024 · 4 citations
  5. 5Genetic variability and response to sertraline in pediatric populations: a review on pharmacogenetics, pharmacokinetics, and the risk of adverse events2026