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July 3, 2026Current Neuropharmacology

Spatial Transcriptomic Dissection of the Cellular and Molecular Architecture of Fear Memory and its Association with Memory Function

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Authors

JCJ ChenJCJ ChenYSYuemeng Sun

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Overview

Randomized trial explores cellular interactions and pathways impacting memory function in mice, highlighting potential therapeutic options.

Key Points

  • This research aims to dissect the cellular and molecular architecture of fear memory and its impact on general memory function.
  • Analyzed spatial transcriptomic data from mouse brain sections using 10xGenomics.
  • Employed Cell2location, CellChat, and Monocle for cellular composition characterization and intercellular communication analysis.
  • Identified potential ligands, receptors, transcription factors, and biomarkers associated with fear memory.
  • Found significant interactions among M2 macrophages, astrocytes, oligodendrocytes, and cholinergic neurons influencing fear memory.
  • Identified Opalin, Thbs4, and Cyp2j12 as upregulated biomarkers in fear memory regions.
  • Demonstrated that EPH/Ephrin-mediated ligand-receptor interactions impair memory function.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a47545e5c29257aa2579f67https://doi.org/10.2174/011570159x435117260616034408
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astrocytes in Fear Memory Processing: Molecular Mechanisms Across the Amygdala–Hippocampus–Prefrontal Cortex Network2025 · 6 citations
  2. 2Continuing the search for the engram: examining the mechanism of fear memories2010 · 4 citations
  3. 3Developmental and molecular contributions to contextual fear memory emergence in mice2024 · 4 citations
  4. 4Progress in spatiotemporal regulation of fear memory: neural circuit mechanisms and implications for PTSD2025
  5. 5Involvement of the Primary Auditory Cortex-Basolateral Amygdala Circuit in Altered Conditioned Fear Memory Retrieval Following Electromagnetic Field Exposure in Mice.2026