What question did this study set out to answer?

The study aims to understand how maternal overweight and gestational weight gain affect the maternal-fetal stress axis and fetal development.

Maternal overweight and obesity during pregnancy and sex‐dependent dysregulation of the materno‐fetal stress axis

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Prospective study assesses maternal obesity effects on stress axis and fetal development, indicating nutritional and stress management strategies.

The study aims to understand how maternal overweight and gestational weight gain affect the maternal-fetal stress axis and fetal development.
Conducted a prospective study involving 175 singleton pregnancies
Analyzed maternal weight, cortisol levels, and placental HSD11B2 expression at various stages of pregnancy and postpartum
Used linear regression and correlation analyses to interpret data
Obese women had higher rates of excessive gestational weight gain and postpartum weight retention
First-trimester hair cortisol was elevated in overweight and obese groups, indicating chronic stress
Macromia and small for gestational age rates were higher among infants of obese mothers, linked to maternal cortisol levels

Braun et al. (2026) studied this question.

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Prospective study assesses maternal obesity effects on stress axis and fetal development, indicating nutritional and stress management strategies.