What question did this study set out to answer?

The study aims to establish a cohort and bioresource for patients with psychosis to understand the underlying mechanisms of severe mental illness.

July 3, 2026BMJ OpenOpen Access

Severe Mental Illness Longitudinal Evaluation (SMILE): protocol for establishing a cohort and bioresource for UK-based patients with psychosis

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The study aims to establish a cohort and bioresource for patients with psychosis to understand the underlying mechanisms of severe mental illness.
Establishment of a cohort of up to 2000 UK-based patients with diagnosed psychosis.
Collection of clinical data using self-report and clinician ratings.
Biosamples will allow for genotyping and wider omics analysis for future research.
Long-term storage of clinical data and biological samples for future targeted trials.
Development of discovery science related to the mechanisms of psychosis using collected data.
Ethical approval ensures compliance and proper handling of participant data and biosamples.

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Randomized trial evaluates psychotic disorders in UK patients, highlighting the need for better understanding and interventions.

Quinn et al. (2026) studied this question.

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