Transaortic chordal cutting combined with shallow septal resection significantly reduced resting outflow gradient from 82 to 9 mm Hg (p<0.001) in severely symptomatic patients with obstructive HCM.
Cohort (n=64)
Effect estimate: decreased from 82 ± 43 mm Hg to 9 ± 5 mm Hg
p-value: p=<0.001
BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM) and mild septal hypertrophy, mitral valve (MV) abnormalities may play an important role in MV displacement into the left ventricular (LV) outflow tract. Therefore, isolated myectomy may not relieve outflow obstruction and symptoms, and MV replacement is often the surgical alternative. OBJECTIVES: This study sought to assess the clinical and hemodynamic results of cutting thickened secondary MV chordae combined with a shallow septal muscular resection in severely symptomatic patients with obstructive HCM and mild septal hypertrophy. METHODS: Clinical features were compared before surgery and at most recent clinical evaluation in 39 consecutive patients with obstructive HCM. RESULTS: Over a 23 ± 2 months follow-up, New York Heart Association functional class decreased from 2.9 ± 0.5 pre-operatively to 1.1 ± 1.1 post-operatively (p < 0.001), with no patient in class III at most recent evaluation. The resting outflow gradient decreased from 82 ± 43 mm Hg to 9 ± 5 mm Hg (p < 0.001) and septal thickness decreased from 17 ± 1 mm to 14 ± 2 mm (p < 0.001). No patient had MV prolapse or flail and 1 had residual moderate-to-severe MV regurgitation at most recent evaluation. MV geometry before and after surgery was compared with that of 25 consecutive patients with similar clinical profile and septal thickness that underwent isolated myectomy. After adjustment for differences in pre-operative values between the groups, the post-operative anterior MV leaflet-annulus ratio was 17% greater and tenting area 24% smaller in patients with chordal cutting, indicating that MV apparatus had moved to a more normal posterior position within the LV cavity, preventing MV systolic displacement into the outflow tract and outflow obstruction. CONCLUSIONS: This procedure relieves heart failure symptoms, abolishes LV outflow gradient, and avoids MV replacement in patients with obstructive HCM and mild septal thickness.
“Transaortic cutting of MV secondary chordae is a novel technique for MV repair that, associated with a shallow septal myectomy, abolishes the outflow gradient, relieves heart failure symptoms, and avoids MV replacement in patients with obstructive HCM and mild septal thickness.”
Ferrazzi et al. (Thu,) conducted a cohort in obstructive hypertrophic cardiomyopathy and mild septal hypertrophy (n=64). Transaortic chordal cutting combined with shallow septal muscular resection vs. Isolated myectomy was evaluated on Resting outflow gradient (decreased from 82 ± 43 mm Hg to 9 ± 5 mm Hg, p=<0.001). Transaortic chordal cutting combined with shallow septal resection significantly reduced resting outflow gradient from 82 to 9 mm Hg (p<0.001) in severely symptomatic patients with obstructive HCM.