Key result
Insulin restored depressed IKr/HERG function and prevented QTc prolongation and associated arrhythmias in a rabbit model of type 1 diabetes, partially through its antioxidant ability.
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Should not change QT management in diabetes; leaves open insulin's role pending human trials.
Zhang et al. (2006) studied Type 1 insulin-dependent diabetes mellitus with abnormal QT prolongation. Insulin was evaluated on QTc interval, action potential duration, and associated arrhythmias. Insulin restored depressed IKr/HERG function and prevented QTc prolongation and associated arrhythmias in a rabbit model of type 1 diabetes, partially through its antioxidant ability.
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