Key result
Percutaneous intramyocardial septal radiofrequency ablation resolves syncope and LVOT obstruction in HOCM despite haemodynamic collapse.
Why the study?
To report an unusual presentation of systolic anterior motion associated with acute haemodynamic collapse in a patient with hypertrophic obstructive cardiomyopathy.
Case Report (n=1)
Proximal displacement of the anterior mitral leaflet is a rare, severe form of systolic anterior motion that can cause acute haemodynamic collapse following percutaneous intramyocardial septal radiofrequency ablation for HOCM.
Background: Systolic anterior motion (SAM) of the mitral valve is a hallmark feature of hypertrophic obstructive cardiomyopathy (HOCM) and a primary cause of dynamic left ventricular outflow tract obstruction. This case report highlights an unusual presentation of SAM associated with acute haemodynamic collapse. Case summary: A 36-year-old male with HOCM presented with recurrent episodes of syncope. After a multidisciplinary evaluation, he underwent percutaneous intramyocardial septal radiofrequency ablation (PIMSRA). Approximately 1-h post-procedure, the patient developed severe haemodynamic collapse. Transthoracic echocardiography revealed abnormal proximal displacement of the anterior mitral valve leaflet, bringing it into close proximity with the septum. The patient was treated emergently with high-dose intravenous norepinephrine, stabilizing his condition. At the 18-month follow-up, the patient reported no recurrence of syncope. Discussion: Proximal displacement of the anterior mitral leaflet, a rare and severe form of SAM, is an uncommon yet critical complication associated with haemodynamic collapse and syncope. This phenomenon warrants heightened attention during PIMSRA for the treatment of HOCM.
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Li et al. (2025) conducted a case report in Hypertrophic obstructive cardiomyopathy (n=1). Percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) was evaluated on Resolution of syncope and left ventricular outflow tract obstruction. Percutaneous intramyocardial septal radiofrequency ablation successfully resolved recurrent syncope and left ventricular outflow tract obstruction in a patient with HOCM, despite acute post-procedural haemodynamic collapse.
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