Key result
Liver transplantation in children with severe liver disease significantly improved cardiac autonomic modulation, evidenced by increases in heart rate variability parameters including total frequency (P=0.0294) and HFms2 (P=0.0465).
Why the study?
Autonomic dysfunction affects up to 60% of patients with cirrhosis, leading to altered heart rate variability, but HRV changes around liver transplantation in children require evaluation.
Does liver transplantation improve heart rate variability indexes in children with severe liver disease?
Observational (n=17)
No
Does liver transplantation improve heart rate variability indexes in children with severe liver disease?
p-value: p=0.0294
The abstract lacks reported results to determine the effect of liver transplantation on heart rate variability in children with severe liver disease.
Post-LT HRV gains suggest autonomic recovery in children; hypothesis-generating, needs prospective validation before practice change.
Background: The cardiovascular system is directly influenced by the autonomic nervous system (ANS); its changes affect heart rate variability (HRV) and are sensitive indicators of physiological changes. Autonomic dysfunction (AD) is manifested in up to 60% of patients with cirrhosis. Therefore, we aim to analyze the indexes of HRV pre- and post-surgery of children submitted for liver transplantation (LT). Methods: HRV, in children of both genders from 6 months of age to 10 years, that attended at the pediatric surgery clinic in the queue for LT at the Children's Institute were analyzed. To access HRV we analyzed indexes such as standard deviation of the RR intervals (SDNN), root-mean-square of the successive normal sinus RR interval difference (RMSSD), low frequency (LF), high frequency (HF), and LF/HF. Results: index. Conclusions: index, parasympathetic tone of the HRV.
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Salatini et al. (2022) conducted an observational in Severe liver disease (n=17). Liver transplantation vs. Pre-transplant baseline was evaluated on Heart rate variability (total frequency) (p=0.0294). Liver transplantation in children with severe liver disease significantly improved cardiac autonomic modulation, evidenced by increases in heart rate variability parameters including total frequency (P=0.0294) and HFms2 (P=0.0465).
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