Key result
Low-dose flecainide added to atenolol eliminates a ~29% PVC burden and normalizes LV systolic function.
Why the study?
Does low-dose flecainide added to a beta-blocker eliminate PVCs and improve left ventricular function in a juvenile athlete with high-burden LVOT PVCs?
Population
One 6-year-old male athlete with frequent PVCs and reduced left ventricular systolic function
Comparison
Add-on flecainide 25 mg twice daily to atenolol vs atenolol alone
Design
Case report
Follow-up
Until 12 years of age
Authors
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Frequent PVCs in asymptomatic child athletes merit evaluation; leaves open optimal pediatric management pending larger studies.
Case Report (n=1)
Does low-dose flecainide added to a beta-blocker eliminate PVCs and improve left ventricular function in a juvenile athlete with high-burden LVOT PVCs?
Absolute Event Rate: 0% vs 29%
Low-dose flecainide added to a beta-blocker safely and effectively eliminated a high burden of LVOT PVCs and reversed PVC-induced cardiomyopathy in a juvenile athlete.
Christou et al. (2025) conducted a case report in Idiopathic ventricular arrhythmias (n=1). Flecainide as add-on to atenolol vs. Atenolol alone was evaluated on PVC burden on 24-h ambulatory electrocardiographic monitoring. The addition of low-dose flecainide to atenolol completely suppressed premature ventricular contractions, reducing the PVC burden from 29% to 0%, and normalized left ventricular systolic function.
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