Association of Triglyceride–to–HDL Cholesterol Ratio With Heart Rate Recovery
Key result
A high triglyceride-to-HDL cholesterol ratio was associated with a significantly higher prevalence of abnormal heart rate recovery (40% vs. 30%; prevalence ratio 1.18; 95% CI 1.01-1.39; P=0.04).
Why the study?
Is a high triglyceride-to-HDL cholesterol ratio associated with abnormal heart rate recovery and increased mortality in healthy adults?
Population
4,963 healthy adults who participated in the Lipid Research Clinics Prevalence Study and underwent exercise…
Comparison
High triglyceride-to-HDL cholesterol ratio vs Lower triglyceride-to-HDL cholesterol ratio
Design
Cohort
Follow-up
12 years
Authors
Discussion
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Member takes
Implication
Abnormal HRR may identify insulin-resistant patients at higher risk; supports hypothesis-generating research on autonomic-metabolic links.
Study Design
Type
Cohort (n=4,963)
Multicenter
Yes
Structured PICO
Is a high triglyceride-to-HDL cholesterol ratio associated with abnormal heart rate recovery and increased mortality in healthy adults?
P
Population
4,963 healthy adults who underwent exercise testing, followed for 12 years.
E
Exposure
High triglyceride-to-HDL cholesterol ratio (highest quartile or continuous increase)
C
Comparator
Lower triglyceride-to-HDL cholesterol ratio
O
Outcome
Abnormal heart rate recovery (HRR), defined as failure to drop ≥ 42 bpm 2 min after completion of exercisesurrogate
Main Result
Relative Risk: 1.18 (95% CI 1.01–1.39)
Absolute Event Rate: 40% vs 30%
p-value: p=0.04
A high triglyceride-to-HDL cholesterol ratio, a marker of insulin resistance, is associated with abnormal heart rate recovery and identifies patients at increased risk of death.
Cite This Study
Shishehbor et al. (2004) conducted a cohort in Healthy adults (n=4,963). High triglyceride-to-HDL cholesterol ratio vs. Lower triglyceride-to-HDL cholesterol ratio was evaluated on Abnormal heart rate recovery (prevalence ratio 1.18, 95% CI 1.01-1.39, p=0.04). A high triglyceride-to-HDL cholesterol ratio was associated with a significantly higher prevalence of abnormal heart rate recovery (40% vs. 30%; prevalence ratio 1.18; 95% CI 1.01-1.39; P=0.04).