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January 1, 2012Medical Science MonitorOpen Access

Long-term echocardiographic changes in left ventricular size and function following surgery for severe mitral regurgitation

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Key result

Following mitral valve surgery for chronic regurgitation, left ventricular fractional shortening improved at an average rate of 1.6% per year (95% CI, 0.2-2.9).

Why the study?

Does mitral valve surgery improve left ventricular size and function over time in patients with chronic severe mitral regurgitation?

Population

108 consecutive patients with chronic severe mitral regurgitation who underwent mitral valve surgery

Comparison

Mitral valve surgery vs Preoperative baseline

Design

Cohort

Authors

PGPuneet GhayalOla Grimsby InstituteAHAli HaiderRice UniversityWAWilbert S. AronowWestchester Medical Center

Discussion

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Overview

Mitral valve surgery for severe chronic mitral regurgitation leads to an immediate reduction in left ventricular size and a gradual long-term improvement in left ventricular function, particularly in patients without concomitant CABG.

Study Design

Type

Cohort (n=108)

Structured PICO

Does mitral valve surgery improve left ventricular size and function over time in patients with chronic severe mitral regurgitation?

P
Population
108 consecutive patients with chronic mitral regurgitation who underwent mitral valve surgery, evaluated with 454 pre- and postoperative echocardiograms.
E
Exposure
Mitral valve surgery
C
Comparator
Preoperative baseline (pre- and postoperative echocardiograms compared)
O
Outcome
Changes in left ventricular size (diastolic diameter) and function (fractional shortening) over timesurrogate

Main Result

Effect estimate: 1.6% per year (95% CI 0.2-2.9)

Mitral valve surgery for severe chronic mitral regurgitation leads to an immediate reduction in left ventricular size and a gradual long-term improvement in left ventricular function, particularly in patients without concomitant CABG.

Limitations

  • Subgroups were small
  • Small subgroup sizes

Cite This Study

Ghayal et al. (2012) conducted a cohort in chronic mitral regurgitation (n=108). Mitral valve surgery vs. Preoperative baseline was evaluated on Change in left ventricular fractional shortening over time (1.6% per year, 95% CI 0.2-2.9). Following mitral valve surgery for chronic regurgitation, left ventricular fractional shortening improved at an average rate of 1.6% per year (95% CI, 0.2-2.9).

synapsesocial.com/papers/6a484e81a567c8cbc92f7ee8https://doi.org/10.12659/msm.882620

Topics

Mitral valve interventionEchocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Congestive Heart Failure After Surgical Correction of Mitral Regurgitation1995 · 143 citations
  2. 2Early and Late Results of Restrictive Mitral Valve Annuloplasty in 121 Patients with Cardiomyopathy and Chronic Mitral Regurgitation2008 · 23 citations
  3. 3Five-year echocardiographic results of combined undersized mitral ring annuloplasty and coronary artery bypass grafting for chronic ischaemic mitral regurgitation2007 · 134 citations
  4. 4Prediction of outcome after mitral valve replacement in patients with symptomatic chronic mitral regurgitation. The importance of left atrial size.1991 · 173 citations
  5. 5Left Ventricular Reverse Remodeling but Not Clinical Improvement Predicts Long-Term Survival After Cardiac Resynchronization Therapy2005 · 707 citations