Key result
Calcium-release channels from the canine interventricular septum have a significantly smaller conductance (31 pS vs 100 pS) and longer open and closed times than those from the left-ventricular free wall.
Absolute Event Rate: 31% vs 100%
p-value: p=<0.001
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Suggests heterogeneous calcium-release properties across cardiac regions; leaves open functional consequences for septal myocardium in health and disease.
Borgatta et al. (1991) studied this question. Sarcoplasmic reticulum vesicles from interventricular septum vs. Sarcoplasmic reticulum vesicles from left-ventricular free wall was evaluated on Single-channel conductance (pS) (p=<0.001). Calcium-release channels from the canine interventricular septum have a significantly smaller conductance (31 pS vs 100 pS) and longer open and closed times than those from the left-ventricular free wall.
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