Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1986The Journal of General PhysiologyOpen Access

Single channel measurements of the calcium release channel from skeletal muscle sarcoplasmic reticulum. Activation by Ca2+ and ATP and modulation by Mg2+.

View Full Paper
Ask AI
Bookmark
Share

Population

Heavy-density skeletal muscle sarcoplasmic reticulum fractions incorporated into planar lipid bilayers of…

Design

Preclinical

Authors

JSJeffrey S. SmithUniversity of VirginiaRCRoberto CoronadoNew Mexico State UniversityGMGerhard MeissnerElectrophysiology

Discussion

Loading...

Member takes

Overview

Advances in vitro SR Ca2+ release channel regulation; leaves open translation to human excitation-contraction coupling.

Structured PICO

P
Population
Heavy-density skeletal muscle sarcoplasmic reticulum (SR) fractions incorporated into planar lipid bilayers of the Mueller-Rudin type
I
Intervention
Activation by Ca2+ (2-950 microM) and ATP (millimolar), and modulation by Mg2+
O
Outcome
Channel open probability (Po) and single channel lifetimessurrogate

The study characterizes the activation of the skeletal muscle SR calcium release channel by Ca2+ and ATP, and its inhibition by Mg2+, providing fundamental biophysical insights into muscle excitation-contraction coupling.

Cite This Study

Smith et al. (1986) studied this question.

synapsesocial.com/papers/6a7699b22e130d02afec12eehttps://doi.org/10.1085/jgp.88.5.573
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Properties of single calcium‐activated potassium channels in cultured rat muscle1982 · 715 citations
  2. 2Mechanisms of Ca2+ release from sarcoplasmic reticulum of skeletal muscle1984 · 329 citations
  3. 3Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.1985 · 326 citations
  4. 4Slow calcium and potassium currents across frog muscle membrane: measurements with a vaseline‐gap technique.1981 · 182 citations
  5. 5Channel Selectivity and Gating Specificity of Calcium-Induced Calcium Release Channel in Isolated Sarcoplasmic Reticulum11984 · 36 citations