October 1, 1986Proceedings of the National Academy of SciencesOpen Access

Single calcium channels in native sarcoplasmic reticulum membranes from skeletal muscle.

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Population

Native sarcoplasmic reticulum membranes from rabbit skeletal muscle

Design

Preclinical

Authors

BSBenjamín A. Suárez‐IslaUniversity of Chile COC OrozcoNational Institute on Aging PHPhillip F. HellerBaltimore City Health Department

Discussion

Member takes

Implication

Does not support clinical translation; leaves open the channel's role in human excitation-contraction coupling.

Structured PICO

Population

Native sarcoplasmic reticulum membranes from rabbit skeletal muscle

Intervention

Patch-clamp technique with application of caffeine (1.6 mM), dantrolene (50 microM), and nitrendipine (10 microM)

Outcome

Electrical properties of the calcium channel (conductance, burst duration, burst frequency)surrogate

Identifies and characterizes a spontaneously active calcium channel in rabbit skeletal muscle sarcoplasmic reticulum that may mediate calcium release during excitation-contraction coupling.

Cite This Study

Suárez‐Isla et al. (1986) studied this question.

synapsesocial.com/papers/6a83f89a47147a06038de2ae https://doi.org/10.1073/pnas.83.20.7741

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Single calcium channels in native sarcoplasmic reticulum membranes from skeletal muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Single calcium channels in native sarcoplasmic reticulum membranes from skeletal muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider