Single calcium channel behavior in native skeletal muscle.

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Population

Cultured skeletal muscle myotubes

Design

Preclinical

Authors

Discussion

Distinguishes T- and L-type Ca channels in skeletal muscle; leaves open their roles in human disease and therapeutic targeting.

Population

Cultured skeletal muscle myotubes

Intervention

Whole-cell and cell-attached patch clamp recordings with 110 mM BaCl2, Bay K 8644 (5 microM), and (+)-PN 200-110 (10 microM)

Outcome

Macroscopic and unitary behavior of voltage-dependent calcium channelssurrogate

This study characterizes the single-channel and macroscopic properties of T-type and L-type calcium channels in native skeletal muscle.

Dirksen et al. (1995) studied this question.

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