Population
Primary cultures of thigh muscle of newborn rats (myoballs)
Comparison
Dihydropyridine Ca2+ channel inhibitor-PN… vs Control conditions without drug application
Design
Preclinical
Authors
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May inform DHP dosing in muscle disorders; extends cardiac observations to skeletal muscle but leaves open human translation.
The study demonstrates that dihydropyridine-sensitive Ca2+ channels in mammalian skeletal muscle have voltage-dependent interactions with inhibitors, similar to cardiac Ca2+ channels.
Cognard et al. (1986) studied this question.
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