Key result
Intracoronary injection of autologous porcine endothelial progenitor cells or their conditioned media significantly increased infarct territory mass and improved regional systolic function at 2 months.
Why the study?
Does intracoronary injection of autologous endothelial progenitor cells or their conditioned media improve regional ventricular systolic function and infarct territory mass in a porcine model of acute myocardial infarction?
Does intracoronary injection of autologous endothelial progenitor cells or their conditioned media improve regional ventricular systolic function and infarct territory mass in a porcine model of acute myocardial infarction?
Absolute Event Rate: 19.6% vs 0%
p-value: p=<0.05
Endothelial progenitor cells improve regional function post-myocardial infarction in a porcine model via paracrine secretion of TGFbeta1, which induces cardiomyocyte hypertrophy.
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EPC therapy induces post-MI hypertrophy via paracrine factors in pigs; challenges direct repair assumptions and leaves open clinical translation.
Doyle et al. (2008) studied Acute myocardial infarction (n=35). Autologous porcine endothelial progenitor cells (EPC) or conditioned media vs. 0.9% normal saline was evaluated on Change in infarct-related territory (IRT) mass from baseline to 2 months (g) (p=<0.05). Intracoronary injection of autologous porcine endothelial progenitor cells or their conditioned media significantly increased infarct territory mass and improved regional systolic function at 2 months.
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