Key result
Septal myectomy with subvalvular intervention reduced the peak gradient to 8.7±4.5 mm Hg and resulted in a 10% prevalence of residual mitral regurgitation at 1-year follow-up.
Why the study?
Subvalvular abnormalities of the mitral valve may contribute to residual left ventricular outflow tract obstruction after surgical septal myectomy in hypertrophic obstructive cardiomyopathy.
Does septal myectomy with subvalvular intervention improve hemodynamics and symptoms in patients with hypertrophic obstructive cardiomyopathy?
Observational (n=40)
Does septal myectomy with subvalvular intervention improve hemodynamics and symptoms in patients with hypertrophic obstructive cardiomyopathy?
Concomitant subvalvular intervention during septal myectomy effectively eliminates LVOT obstruction and provides high freedom from residual mitral regurgitation at one year.
Subvalvular intervention may reduce residual MR after myectomy; leaves open whether it improves long-term outcomes in HOCM.
Aim . Surgical septal myectomy is a standard treatment option for patients with hypertrophic obstructive cardiomyopathy. Subvalvular abnormalities of the mitral valve may play an important role in residual left ventricular outflow tract obstruction. This study aimed to evaluate the surgical outcomes of septal myectomy with subvalvular interventions. Material and Methods . Between July, 2015 and December, 2016, 40 eligible patients underwent septal myectomy with subvalvular intervention. The peak gradient was 92.3±16.9 mm Hg. The mean septum thickness was 26.8±4.5 mm. Moderate or severe systolic anterior motion syndrome-mediated mitral regurgitation was observed in all patients. Results . There was no residual mitral regurgitation. Residual systolic anterior motion syndrome was observed in 5%. The postoperative gradient was 8.7±4.5 mm Hg. At 12-month follow-up, all patients were alive. According to the New York Heart Association (NYHA) classification, 87.5 and 12.5% of patients had NYHA functional classes I and II, respectively. The prevalence rate of residual mitral regurgitation was 10%. Conclusions . Concomitant subvalvular intervention during septal myectomy effectively eliminated left ventricular outflow tract obstruction and provided high freedom from residual mitral regurgitation one year after surgery.
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Afanasyev et al. (2018) conducted an observational in Hypertrophic obstructive cardiomyopathy (n=40). Septal myectomy with subvalvular intervention was evaluated on Residual mitral regurgitation at 12 months. Septal myectomy with subvalvular intervention reduced the peak gradient to 8.7±4.5 mm Hg and resulted in a 10% prevalence of residual mitral regurgitation at 1-year follow-up.
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