Key result
High BMI linked to ~67% increase in global atrial fibrillation mortality rate since 1990.
Why the study?
This study evaluated global changes in the burden of high body mass index and its impact on atrial fibrillation and flutter using the 2021 Global Burden of Disease database.
Does high BMI increase the global mortality and morbidity burden of atrial fibrillation and flutter over time?
Observational
Does high BMI increase the global mortality and morbidity burden of atrial fibrillation and flutter over time?
The rapidly escalating global burden of high BMI independently and significantly contributes to increased AF/AFL mortality and morbidity, underscoring the necessity for targeted weight management public health strategies.
High BMI may contribute to rising global AF/AFL mortality; leaves open whether weight management reduces population burden.
BACKGROUND: This study evaluates changes in the burden of high body mass index (BMI) and its impact on atrial fibrillation and flutter (AF/AFL) using the 2021 Global Burden of Disease database. METHODS: Mortality and disability-adjusted life years rates were analysed globally, considering age, sex, geography and the Socio-demographic Index (SDI). Decomposition and frontier analyses assessed the impact of epidemiological drivers and SDI on the burden. The nordpred model validated the predictions. RESULTS: The burden of high BMI is now 2.5 times greater than 30 y ago and will continue to increase over the next 20 y, heavily impacting cardiovascular and metabolic diseases. High BMI-related AF/AFL also poses a significant burden, especially in developed regions. Men's burden grows faster than women's. Decomposition analysis shows epidemiological changes mainly drive burden increases, while in women, population growth is more significant. Frontier analysis indicates that the gap between actual burden and theoretical optimal value has widened with increasing SDI, except in countries such as Bulgaria and the Czech Republic. CONCLUSIONS: Over the past 30 y, the overall burden of high BMI and its impact on AF/AFL have increased significantly, highlighting the need for targeted public health strategies.
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He et al. (2025) conducted an observational in Atrial fibrillation and flutter (AF/AFL) and high body mass index. High body mass index (BMI) vs. Historical rates in 1990 was evaluated on Age-standardized mortality rate (ASMR) per 100,000 for AF/AFL attributable to high BMI (Estimated annual percentage change (EAPC) 1.65%, 95% CI 1.6-1.71). High body mass index exposure increased the age-standardized mortality rate of atrial fibrillation and flutter globally from 0.21 to 0.35 per 100,000 between 1990 and 2021.
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