Background/Aim: metastatic breast cancer (dnMBC) remains unclear. We conducted a systematic review and meta-analysis to evaluate whether surgery and/or radiotherapy of the primary tumor improves overall survival (OS). Materials and Methods: , and meta-regression was used to explore potential moderators. Results: =91.5%), these findings need to be interpreted with caution. Subgroup analyses showed a non-significant trend in hormone receptor-positive disease (HR=0.78; 95% CI=0.58-1.04) and no benefit in HER2-positive (HR=0.90; 95% CI=0.61-1.33) or liver-limited disease (HR=1.17; 95% CI=0.77-1.78). No covariates were significantly associated with OS in meta-regression. Conclusion: Although pooled analyses suggest an association between local treatment and improved OS, this effect appears largely driven by retrospective data and is not confirmed in randomized trials.
Sisca et al. (Thu,) studied this question.