Direct Synthesis of N -Acylhydrazones from N -Substituted Hydrazines, Aldehydes, and Carboxylic Acids via Preferential Imine Formation and Selective Secondary Amine Monoacylation

Yan-Biao Chen; Fang Wang; Chun Hong; Hao-Nan Peng; Yin-Jia Chen; Kun Zhang; Xian-Zao Luo; Bao‐Dong Cui; Xue-Qing Mou; Yun Zhang; Yong‐Zheng Chen

doi:10.1021/acs.joc.6c01080

July 2, 2026The Journal of Organic Chemistry

Direct Synthesis of N -Acylhydrazones from N -Substituted Hydrazines, Aldehydes, and Carboxylic Acids via Preferential Imine Formation and Selective Secondary Amine Monoacylation

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Key Points

The aim is to develop a method for synthesizing N-acylhydrazones directly from N-substituted hydrazines and functionalized substrates.
Utilized preferential imine formation for synthesis.
Implemented selective secondary amine monoacylation.
Demonstrated broad substrate scope and functional group tolerance.
Successfully synthesized various N-acylhydrazones.
Constructed valuable bioactive molecules efficiently.
Achieved late-stage functionalization of pharmaceuticals with high utility.

Implication

Synthesis method demonstrates efficient creation of N-acylhydrazones in pharmaceuticals, suggesting enhanced bioactivity potential.

Abstract

-substituted hydrazones. The reaction has a wide substrate scope and functional group tolerance. The synthetic utility has been illustrated by the facile construction of valuable bioactive molecules and late-stage functionalization of pharmaceuticals.

Discussion

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a48a3cb89561a0c2d78d800 https://doi.org/10.1021/acs.joc.6c01080

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Direct Synthesis of N -Acylhydrazones from N -Substituted Hydrazines, Aldehydes, and Carboxylic Acids via Preferential Imine Formation and Selective Secondary Amine Monoacylation

Key Points

Implication

Abstract

Discussion

Cite This Study

Direct Synthesis of N -Acylhydrazones from N -Substituted Hydrazines, Aldehydes, and Carboxylic Acids via Preferential Imine Formation and Selective Secondary Amine Monoacylation

Key Points

Implication

Abstract

Discussion

Cite This Study

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