Synthesis of Acyl Hydrazides and Hydrazones from Activated Amides

Acyl hydrazide and acyl hydrazone synthesis methods were developed. They involve the reaction of an activated amide with hydrazine under transition-metal-catalyst-free conditions. Additionally, acyl hydrazones were synthesized by extending the same reaction procedure in the presence of aldehydes (or ketones). These reactions were performed in an aqueous environment at 25 °C, demonstrating the successful attainment of the desired compounds with high yields.