What question did this study set out to answer?

This meta-analysis investigates factors associated with the occurrence of malignancy in systemic sclerosis.

Clinical and autoantibody associations with malignancy in systemic sclerosis: A systematic review and meta-analysis

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Meta-analysis examines malignancy factors in systemic sclerosis, suggesting a risk-stratified surveillance approach.

This meta-analysis investigates factors associated with the occurrence of malignancy in systemic sclerosis.
Conducted a systematic search across Embase, MEDLINE, and Cochrane Library databases.
Included case-control and cohort studies that reported associations with malignancy in systemic sclerosis.
Performed random-effects meta-analyses to pool results and calculate mean differences and odds ratios.
SSc patients with malignancy were older by an average of 4.01 years (MD 95% CI 1.24–6.78).
Significant risk factors for malignancy included male gender (OR 1.36), smoking (OR 1.27), pulmonary hypertension (PH, OR 1.32), and interstitial lung disease (ILD; OR 1.41).
Anti-RNAPIII was notably associated with breast malignancy (OR 2.17) and an increased risk in early malignancy detection (OR 2.85).

Raghupathy et al. (2026) studied this question.

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