Key result
Pentaspline pulsed-field ablation achieves ~83% durable pulmonary vein isolation at repeat procedure.
Why the study?
Although pulsed-field ablation has shown favourable lesion durability for pulmonary vein isolation in atrial fibrillation, the anatomical distribution of pulmonary vein reconnection after index ablation with pentaspline catheter systems remained incompletely characterized.
What are the pulmonary vein reconnection rates and anatomical lesion gap patterns in patients with atrial fibrillation undergoing repeat ablation after index pentaspline pulsed-field ablation?
Cohort (n=258)
No
What are the pulmonary vein reconnection rates and anatomical lesion gap patterns in patients with atrial fibrillation undergoing repeat ablation after index pentaspline pulsed-field ablation?
Identifies reproducible anatomical reconnection hotspots (carinae, LSPV/roof junction, and anterior RSPV) after pentaspline pulsed-field ablation, guiding targeted workflow adjustments to improve lesion durability.
Answers are grounded in this paper and cite their sources.
Reconnection hotspots after pentaspline PFA may inform repeat ablation targeting; leaves open whether workflow refinements improve durability in prospective trials.
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Lucius et al. (2026) conducted a cohort in Paroxysmal and persistent atrial fibrillation (n=258). Pentaspline pulsed-field ablation (Farapulse) for pulmonary vein isolation was evaluated on Number of reconnected pulmonary veins and exact anatomical lesion gap location at repeat ablation. Pentaspline pulsed-field ablation resulted in 82.6% durable vein isolation among 59 repeat-ablation patients, with 17.4% of veins reconnecting mainly at the carina, LSPV/roof, and anterior RSPV.
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