Key result
High-density mapping-guided targeted segmental SVCI achieves 100% ablation success without complications.
Why the study?
Superior vena cava isolation is associated with complications such as sinus node and phrenic nerve injury or SVC stenosis, motivating the assessment of high-density mapping for targeted isolation by ablating preferential conduction sites to avoid complications.
Does high-density mapping-guided targeted segmental ablation safely achieve superior vena cava isolation in patients undergoing atrial fibrillation re-ablation?
Observational (n=83)
Does high-density mapping-guided targeted segmental ablation safely achieve superior vena cava isolation in patients undergoing atrial fibrillation re-ablation?
High-density mapping-guided targeted segmental superior vena cava isolation is a feasible and safe approach that effectively avoids sinus node and phrenic nerve injury during AF re-ablation.
High-density mapping may enable safe targeted SVC isolation in re-ablation; hypothesis-generating and requires larger trials before practice change.
Introduction Superior vena cava isolation (SVCI) is associated with complications such as sinus node (SN) and phrenic nerve (PN) injury or SVC stenosis. Our study assessed the electrophysiological properties of the SVC and use of high-density mapping for targeted SVCI by ablating preferential conduction sites to avoid these complications. Methods Eighty-three consecutive patients, undergoing HD mapping of the SVC during AF re-ablation procedures were prospectively included. Conduction block (CB) lines between the right atrium and SVC, location of the sinus node (SN) and phrenic nerve (PN), and their spatial relationship to the ablation line (AbL) were assessed. Results CB lines were present in 98% of patients, with gaps identified in all SVC segments, most frequently posterior (73%), with a median gap width of 23.9 (14.3–37.8) mm. All gaps expressed decremental properties in the EP study. Ablation was performed in 35 (42%) patients and was achieved in all cases using targeted segmental ablation, closing the gaps between the CB lines.Median ablation duration was 88 (66; 161) seconds with a median of 8 (6–12) radiofrequency applications. SN was separated from SVC with CB line in 98% of cases, what excluded necessity to ablate in this area, distance from the AbL to the SN exit zone was 8.9 (6-14.7) mm. PN was located outside the areas of preferential conduction in all cases, distance from AbL to the PN was 10.4 (6.7–12.1) mm. No complications occurred. Conclusions HD mapping-guided, targeted segmental SVCI using RF energy is feasible and safe.
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Maslova et al. (2026) conducted an observational in Atrial fibrillation (n=83). High-density mapping-guided targeted segmental superior vena cava isolation was evaluated on Feasibility and safety of targeted segmental superior vena cava isolation. High-density mapping-guided targeted segmental superior vena cava isolation is feasible and safe, achieving successful ablation in all 35 targeted patients with no complications.
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