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July 4, 2026Cancer Research

Abstract P03: Chemotherapy-Induced CD70 Expression Enhances Anti-Tumor Immunity and CAR-T Cell Efficacy in Acute Myeloid Leukemia

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Authors

CWChuqi WangJTJordan Yong Ming TanPVPrevitha Dawn Sakthi Vale

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Overview

Randomized trial demonstrates enhanced CAR-T cell efficacy in AML with CD70 expression post-chemotherapy, suggesting a new treatment approach.

Key Points

  • This research aims to explore how chemotherapy-induced CD70 expression affects CAR-T cell efficacy in acute myeloid leukemia.
  • Conducted genome-wide CRISPR knockout screening to identify p53 as the regulator of CD70 expression.
  • Used in vivo syngeneic mouse models to evaluate CD70's role in AML cell engraftment and immune responses.
  • Developed CD70-directed CAR-T cells and examined their efficacy in AML patient samples.
  • CD70 expression was significantly higher in TP53 wild-type AML samples post-chemotherapy, correlating with time from treatment.
  • p53-activating agents increased CD70 expression and enhanced the effectiveness of CAR-T cells.
  • Patients with wild-type TP53 and high CD70 expression post-chemotherapy showed significantly better outcomes.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a48a51b89561a0c2d78dfb6https://doi.org/10.1158/1538-7445.fcs2025-p03
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