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Identifies increased 18F-PSMA uptake in an unexpected penile lesion in an older man, suggesting the need for careful imaging interpretation.
An 86-year-old man with biochemically recurrent prostate cancer underwent an 18 F-DCFPyL (piflufolastat F-18, also known as 18 F-PSMA) PET/CT scan for re-staging purposes and to guide further treatment planning. At the time of imaging, his serum prostate-specific antigen (PSA) level was 3 ng/mL. The PET/CT scan incidentally revealed a focus of increased 18 F-DCFPyL uptake corresponding to a soft tissue nodule within the right aspect of the penile shaft. An initial ultrasound-guided fine needle aspiration of the nodule was nondiagnostic. The patient subsequently underwent surgical excision of the lesion with wide local resection. Histopathologic analysis confirmed the diagnosis of a traumatic neuroma.
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Zurita et al. (2026) studied this question.
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