Abstract Background: OSCC is a significant health problem in LMICs including India, and has poor outcome due to lack of diagnostic marker. We identified 135 dysregulated candidate proteins in the saliva of OSCC patients using LCMS, of which Lipocalin 2 (LCN2) and Matrix Metalloproteinase 9 (MMP9) were significantly upregulated. We explored the potential role of these proteins as probable biomarker in OSCC. Methodology: 351 OSCC, 26 OPMDs and 118 healthy controls were recruited. 5ml unstimulated saliva and 3ml blood were collected at baseline and during follow-ups. Protein levels were measured by sandwich ELISA, and analysed using appropriate statistical tests. Results: LCN2 was significantly higher (p≤0. 0001) in saliva and serum (median-609. 15ng/ml 0. 0001) AUC of (0. 8025 2025 Nov 5-7; Singapore. Philadelphia (PA): AACR; Cancer Res 2026;86 (13Suppl): Abstract nr P41.
Suri et al. (Thu,) studied this question.