Why the study?
Assessing atrial remodeling in small animals is challenging without specialized tools, and conventional invasive EPS causes trauma and limits longitudinal evaluation.
Is a non-invasive multi-modality assessment using clinical-grade echocardiography and TEP-based EPS feasible and safe for phenotyping atrial myopathy in a rat model of metabolic syndrome?
Population
12 male Sprague-Dawley rats
Comparison
Metabolic syndrome group vs controls
Design
Preclinical comparative study
Key result
Metabolic syndrome in a rat model was associated with shorter atrial effective refractory periods (73.33 vs 120.00 ms; p=0.010) and increased AF inducibility (50% vs 33.3%) compared to controls.
Authors
Loading...
New protocols may ease AF remodeling assessment in small animals; leaves open translation to clinical models.
Is a non-invasive multi-modality assessment using clinical-grade echocardiography and TEP-based EPS feasible and safe for phenotyping atrial myopathy in a rat model of metabolic syndrome?
Absolute Event Rate: 73.33% vs 120%
p-value: p=0.010
Repurposing clinical-grade echocardiography and transesophageal pacing provides a safe and feasible non-invasive method for comprehensive phenotyping of atrial myopathy in small animal models.
Rizal et al. (2026) studied Atrial myopathy in metabolic syndrome (n=12). Metabolic syndrome (MetS) vs. Controls (SH group) was evaluated on Atrial effective refractory period (AERP) in ms (p=0.010). Metabolic syndrome in a rat model was associated with shorter atrial effective refractory periods (73.33 vs 120.00 ms; p=0.010) and increased AF inducibility (50% vs 33.3%) compared to controls.