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July 2, 2026Journal of Medicinal Chemistry

Rational Development of Activatable Prodrugs of the GSTP1 Inhibitor NBDHEX: Turn-On NIR Fluorogenic Drug Delivery with Selective Anticancer Activity

Rahul Kesarwani Nikita Pal Dorothy Das Asis Bala Krishna P. Bhabak

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Key Points

The study aims to develop and evaluate activatable prodrugs of the GSTP1 inhibitor NBDHEX for selective anticancer therapy.
Evaluated the design and synthesis of NBDHEX prodrugs.
Utilized near-infrared (NIR) fluorescence for drug delivery monitoring.
Assessed anticancer efficacy in vitro and in vivo without acute toxicities.
Demonstrated selective anticancer activity of NBDHEX prodrugs.
Observed no noticeable abnormalities or acute toxicities in trials.

Implication

Explores selective anticancer activity of NBDHEX prodrugs, suggesting potential for targeted therapy.

Abstract

without any noticeable abnormalities or acute toxicities, supporting the translational potential of the prodrug.

Discussion

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Cite This Study

Kesarwani et al. (2026) studied this question.

synapsesocial.com/papers/6a48a83589561a0c2d78ef58 https://doi.org/10.1021/acs.jmedchem.6c01286

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