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July 4, 2026Cancer Research

Abstract P95: PDCD11, Enriched in Cancer cell-Derived Extracellular Vesicles, Promotes Immunosuppressive Macrophage Polarization and Tumor Immune Evasion in HBV related Hepatocellular Carcinoma

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Authors

IDIndrashish DeyBose (United States)DMDebalina MukherjeeTechno India UniversityABArittri BhowmickBose (United States)

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Implication

Randomized trial examines PDCD11's role in M2 macrophage polarization in HBV-related hepatocellular carcinoma, suggesting therapeutic implications.

Key Points

  • This study investigates how PDCD11, found in cancer cell-derived extracellular vesicles, influences macrophage behavior in the tumor microenvironment of HBV-related hepatocellular carcinoma.
  • Utilized various cell lines including Huh7 and HepG2.2.15 for EV isolation and analysis.
  • Conducted proteomic analyses through liquid chromatography-mass spectrometry and interaction validations with co-immunoprecipitation.
  • Performed functionality assays including co-culture with PMA-treated THP-1 cells and evaluated macrophage polarization via flow cytometry and qRT-PCR.
  • PDCD11 was identified as a significantly enriched protein in EVs from HepG2.2.15 cells compared to controls, associating with tumor-promoting effects.
  • EVs containing PDCD11 induced M2 polarization in THP-1 macrophages, promoting expression of immunosuppressive markers.
  • Demonstrated activation of the NF-κB-cREL-MYC signaling pathway linked to macrophage immune evasion characteristics.

Cite This Study

Dey et al. (2026) studied this question.

synapsesocial.com/papers/6a48a83589561a0c2d78efa5https://doi.org/10.1158/1538-7445.fcs2025-p95
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proteome profiling of extracellular vesicles-derived from hepatitis B virus-infected hepatocellular carcinoma cell lines identifies PDCD11 as a carrier of viral RNAs2025
  2. 2Abstract 3519: PD-L2-RGMb interaction modulates anti-cancer immunity through swinging the shift of Th1/Th2 cell balance2026
  3. 3Abstract 5358: The influence of extracellular vesicles on immune cells in PDAC2024
  4. 4Abstract A044: Pancreatic cancer cell-derived EVs facilitate monocyte recruitment to the tumor site2025 · 1 citations
  5. 5Extracellular Vesicles Contribute to Viral-Induced Hepatocellular Carcinoma: Understanding Their Involvement in Viral Hepatitis and Their Potential as Biomarkers for Early Hepatocellular Carcinoma Detection2024 · 4 citations