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December 5, 2025Frontiers in Cell and Developmental BiologyOpen Access

Proteome profiling of extracellular vesicles-derived from hepatitis B virus-infected hepatocellular carcinoma cell lines identifies PDCD11 as a carrier of viral RNAs

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Authors

IDIndrashish DeySDSubhas DasSDSimanti Datta

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Overview

Proteome analysis identifies PDCD11 as a transporter of viral RNAs in hepatocellular carcinoma, suggesting roles for EVs.

Key Points

  • Accumulation of 3.4 times more proteins was noticed in EVs derived from HBV-infected HepG2.2.15 cells.
  • Proteome analysis identified 2,293 proteins in these EVs, highlighting potential pathways in HCC.
  • Assessment employed proteomic techniques, including LC-MS/MS and bioinformatics tools.
  • Findings suggest PDCD11 as a key target for therapies aimed at HBV-infected HCC treatments.

Cite This Study

Dey et al. (2025) studied this question.

synapsesocial.com/papers/694022442d562116f28fbb9dhttps://doi.org/10.3389/fcell.2025.1643823
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract P95: PDCD11, Enriched in Cancer cell-Derived Extracellular Vesicles, Promotes Immunosuppressive Macrophage Polarization and Tumor Immune Evasion in HBV related Hepatocellular Carcinoma2026
  2. 2Extracellular Vesicles Contribute to Viral-Induced Hepatocellular Carcinoma: Understanding Their Involvement in Viral Hepatitis and Their Potential as Biomarkers for Early Hepatocellular Carcinoma Detection2024 · 3 citations
  3. 3Characteristics of extracellular vesicle-derived lncRNAs during the progression of HBV-related hepatocellular carcinoma2025
  4. 4The hijacking of HBV by small extracellular vesicles inhibits M1 macrophages to facilitate immune evasion2024 · 6 citations
  5. 5Identifying key genes involved in HBV-related hepatocellular carcinoma: diagnose, prognosis, interaction and immune analysis2025