Key result
Longer cardiopulmonary bypass linked to lower physical and mental quality of life after cardiac surgery.
Why the study?
Postoperative health-related quality of life remains variably affected after CABG and valve surgery, influenced by multiple clinical and procedural factors.
Cohort
Yes
Preoperative comorbidities, advanced NYHA class, and longer cardiopulmonary bypass duration are significant determinants of worse postoperative health-related quality of life following cardiac surgery.
May inform preoperative risk stratification after cardiac surgery; hypothesis-generating and requires validation before guiding practice.
Background Coronary artery bypass grafting (CABG) and valve surgery provide substantial survival benefits for patients with advanced cardiac disease; however, postoperative health-related quality of life (HRQoL) remains variably affected and is influenced by multiple clinical and procedural factors. This study aimed to evaluate postoperative HRQoL levels during follow-up and identify factors associated with postoperative HRQoL following CABG and valve surgery. Methods In this prospective, multicenter cohort study, postoperative HRQoL was assessed using the validated Short Form-12 (SF-12), generating Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. We did not collect preoperative SF-12 data; therefore, baseline HRQoL was not available for analysis. Demographic characteristics, comorbidities, functional status, and operative variables were collected. Multivariable regression models with center-stratified clustered robust standard errors were used to identify independent factors associated with physical and mental HRQoL. Results Male sex was independently associated with higher PCS scores (β = 1.88), whereas higher body mass index (β = − 0.16), diabetes mellitus (β = − 2.05), renal impairment (β = − 4.36), advanced preoperative NYHA class (NYHA III: β = − 3.79; NYHA IV: β = − 5.96), and longer cardiopulmonary bypass (CPB) duration (β = − 2.11 per 30-min increase) were independently associated with lower PCS scores. For MCS, only CPB duration was independently associated with lower scores (β = − 1.45). Conclusions Postoperative HRQoL levels after CABG and valve surgery were associated with preoperative clinical and functional status, comorbidity burden, and operative complexity. These findings provide prospective multicenter data on postoperative HRQoL in cardiac surgery and may help inform future research on patient-reported recovery. Trial registration Not applicable. This was an observational cohort study and did not involve assignment of participants to an intervention or clinical trial protocol.
No takes yet. Share an insight, caveat, or question.
Khadija et al. (2026) conducted a cohort in Advanced cardiac disease requiring CABG or valve surgery. Clinical, functional, and operative factors (e.g., cardiopulmonary bypass duration) was evaluated on Postoperative health-related quality of life (Physical Component Summary and Mental Component Summary scores). Longer cardiopulmonary bypass duration was independently associated with lower physical (β = -2.11 per 30-min increase) and mental (β = -1.45) quality of life scores after cardiac surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: