Key result
Early catheter ablation reduces mortality and recurrent shocks compared with antiarrhythmic drugs in arrhythmic storm.
Why the study?
Arrhythmic storm is a clinical emergency associated with high mortality that requires multidisciplinary management.
Arrhythmic storm is a clinical emergency that requires prompt multidisciplinary management with sympathetic modulation, antiarrhythmics, and early catheter ablation to improve prognosis.
May support early ablation in arrhythmic storm; hypothesis-generating and requires randomized confirmation before practice change.
Arrhythmic storm is a clinical emergency associated with high mortality, which requires multi-disciplinary management. Reprogramming of the implantable cardiac defibrillator (ICD) aimed at reducing shocks, adrenergic blockade using beta-blockers, sedation/anxiolysis, and blockade of the stellate ganglion represent the first simple and effective manoeuvres, but further suppression of arrhythmias with antiarrhythmics is often required. A low-risk patient (e.g. monomorphic ventricular tachycardia, functioning ICD, and haemodynamically stable) should be managed with a beta-blocker (possibly non-selective) plus amiodarone, in addition to sedation with a benzodiazepine or dexmedetomidine; in patients at greater risk (high burden and haemodynamic instability), autonomic modulation with blockade of the stellate ganglion and the addition of a second antiarrhythmic (lidocaine) should be considered. In patients refractory to these measures, with advanced heart failure, general anaesthesia with intubation and the establishment of a haemodynamic circulatory support should be considered. Ablation, performed early, appears to be superior in terms of mortality and reduction of future shocks compared with titration of antiarrhythmics.
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Lazzari et al. (2024) conducted a review in Arrhythmic storm. Multi-disciplinary management (ICD reprogramming, antiarrhythmics, autonomic modulation, and ablation) was evaluated. Early catheter ablation appears to be superior in terms of mortality and reduction of future shocks compared with titration of antiarrhythmic drugs for the management of arrhythmic storm.
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