Key result
In 5-year survivors of Ewing sarcoma, black race (HR 2.16, P=0.01) and age ≥18 years at diagnosis (HR 2.02, P<0.001) were independently associated with an increased risk of late death.
Why the study?
What are the prognostic factors for late death in patients with Ewing sarcoma who have survived beyond 5 years?
Population
1,351 patients with Ewing sarcoma (EWS) who had survived 60 months or more
Design
Cohort
Follow-up
10 years (from initial diagnosis, for 5-year survivors)
Authors
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Supports risk-stratified survivorship care in Ewing sarcoma; leaves open whether interventions mitigate excess late mortality.
Cohort (n=1,351)
Yes
What are the prognostic factors for late death in patients with Ewing sarcoma who have survived beyond 5 years?
Hazard Ratio: 2.16
p-value: p=0.01
In 5-year survivors of Ewing sarcoma, the majority of late deaths are due to the disease itself, with black race, older age at diagnosis, male sex, and axial/pelvic primary site being independent risk factors for late mortality.
Davenport et al. (2016) conducted a cohort in Ewing sarcoma (n=1,351). Black race vs. Non-black race was evaluated on Late death (HR 2.16, p=0.01). In 5-year survivors of Ewing sarcoma, black race (HR 2.16, P=0.01) and age ≥18 years at diagnosis (HR 2.02, P<0.001) were independently associated with an increased risk of late death.
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