Key result
Topical glibenclamide abolished the dilatation of small coronary arterioles (<100 microns) in response to reductions in perfusion pressure compared to vehicle in anesthetized dogs.
Why the study?
Does glibenclamide alter coronary microvascular autoregulatory responses to reductions in perfusion pressure in open-chest anesthetized dogs?
Does glibenclamide alter coronary microvascular autoregulatory responses to reductions in perfusion pressure in open-chest anesthetized dogs?
ATP-sensitive potassium channels play an important role in mediating autoregulatory vasodilatation of coronary arterioles during reductions in perfusion pressure.
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Implicates KATP channels in canine coronary arteriolar autoregulation; leaves open translation to human microvascular responses.
Komaru et al. (1991) studied this question. Glibenclamide vs. Vehicle (0.01% dimethyl sulfoxide) was evaluated on Arteriolar dilatations during coronary stenoses and occlusions. Topical glibenclamide abolished the dilatation of small coronary arterioles (<100 microns) in response to reductions in perfusion pressure compared to vehicle in anesthetized dogs.
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