Key result
Isthmin-1 is a newly defined adipokine that is widely distributed in the body and plays critical roles in multiple biological processes, including metabolism, immunity, and tumorigenesis.
Why the study?
Isthmin-1 has garnered attention since its 2021 definition as an adipokine playing roles in various pathophysiological processes, prompting a summary of recent knowledge.
This review summarizes recent knowledge on the adipokine Isthmin-1, including its distribution, structure, receptor, and potential functions.
Isthmin-1's adipokine functions warrant further mechanistic study; leaves open any cardiovascular therapeutic role pending targeted trials.
Isthmin-1 is a secreted protein with multiple capability; however, it truly attracts our attention since the definition as an adipokine in 2021, which exerts indispensable roles in various pathophysiological processes through the endocrine or autocrine manners. In this review, we summarize recent knowledge of isthmin-1, including its distribution, structure, receptor and potential function.
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Hu et al. (2022) reported a review. Isthmin-1 (ISM1) was evaluated. Isthmin-1 is a newly defined adipokine that is widely distributed in the body and plays critical roles in multiple biological processes, including metabolism, immunity, and tumorigenesis.
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