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January 8, 2020Journal of Biomedical ScienceOpen Access

Translation control of Enterovirus A71 gene expression

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Key result

Enterovirus A71 utilizes an RNA-centric strategy and manipulates host cell protein factors to promote viral IRES-mediated translation while shutting off host cap-dependent translation.

Why the study?

This review provides an introduction to the known strategies used by Enterovirus A71 to exploit cellular translation mechanisms.

Design

Review

Authors

MLMing‐Chih LaiHCHan-Hsiang ChenPXPeng Xu

Discussion

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Overview

EV-A71 IRES mechanism suggests antiviral targets; leaves open clinical translation pending prospective validation.

Structured PICO

P
Population
EV-A71 infected host cells

This review summarizes the mechanisms by which Enterovirus A71 exploits host cellular translation machinery for viral replication.

Cite This Study

Lai et al. (2020) conducted a review in Enterovirus A71 infection. Enterovirus A71 utilizes an RNA-centric strategy and manipulates host cell protein factors to promote viral IRES-mediated translation while shutting off host cap-dependent translation.

synapsesocial.com/papers/6a499f9ebaf9dfe185df03c9https://doi.org/10.1186/s12929-019-0607-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of the Internal Ribosome Entry Site (IRES)-Dependent Translation of Enterovirus 71 by DDX3X RNA Helicase and Viral 2A and 3C Proteases2018 · 40 citations
  2. 2mRNA Decay Factor AUF1 Binds the Internal Ribosomal Entry Site of Enterovirus 71 and Inhibits Virus Replication2014 · 41 citations
  3. 3PolyC-Binding Protein 1 Interacts with 5′-Untranslated Region of Enterovirus 71 RNA in Membrane-Associated Complex to Facilitate Viral Replication2014 · 60 citations
  4. 4Cleavage of Poly(A)-Binding Protein by Enterovirus Proteases Concurrent with Inhibition of Translation In Vitro1999 · 268 citations
  5. 5A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells2014 · 56 citations