Enterovirus A71 structural and non-structural proteins play crucial roles in viral replication, pathogenesis, and immune evasion, serving as potential targets for vaccines and antiviral therapies.
Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and young children. EV-A71 can also infect the central nervous system (CNS) and induce diverse neurological complications, such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis, or even death. Viral proteins play a crucial role in EV-A71 infection. Many recent studies have discussed the structure and function of EV-A71 proteins, and the findings reported will definitely aid the development of vaccines and therapeutic approaches. This article reviews the progress in the research on the structure and function of EV-A71 proteins. Available literature can provide a basis for studying the pathogenesis of EV-A71 infection in detail.
Yuan et al. (Wed,) conducted a review in Enterovirus A71 (EV-A71) infection. Enterovirus A71 proteins was evaluated. Enterovirus A71 structural and non-structural proteins play crucial roles in viral replication, pathogenesis, and immune evasion, serving as potential targets for vaccines and antiviral therapies.